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The group of chemicals known collectively as neurotransmitters form the basis of a complex communication system between nerve cells. It is a system that is constantly subtly refined and regulated via the modulating action of other neurotransmitters, circulating hormones, the products of local tissues and the action of various drugs (from both medicinal and socially abused sources). In this book, acknowledged authorities concisely describe the basic mechanisms involved in neurotransmitter release modulation in the different parts of the nervous system. This includes a quantitative evaluation of the significance of modulation, a summary of its biological ramifications and potential clinical relevance.